Body composition and joint involvement related to functional well-being in pediatric inflammatory bowel disease
Boros Kriszta Katinka
Rácz Károly Klinikai Orvostudományi
Dr. Reusz György
Gyermekgyógyászati Klinika, Bókay utcai részleg, Tanterem
2025-01-15 14:00:00
Krónikus betegségek gyermekkori prevenciója
Dr. Szabó Attila
Dr. Müller Katalin Eszter
Dr. Bajor Judit
Dr. Svébisné Lovász Barbara
Dr. Szabó Dóra
Dr. Golovics Petra
Dr. Müllner Katalin
HRQoL and prognostic factors, such as nutritional status are in the center of
attention in patient care. BC analysis can not be omitted in the evaluation of nutritional
status. Therefore our primary aim was to analyzise BC in patinets with IBD. We verified,
that BC parameters depend on age, sex, and body size. Due to its dependence on changes
in body size with aging, they have to be normalized by BMI Z score. In the lack of
definition and gold standard measurement methods of sarcopenia in pediatric patients,
BMI normalized SMM Z score may serve as an objective estimation of muscle loss. The
determination of cut-off values may be the subject of future studies.
Using the BMI based BC Z scores, our results showed increasing FFM Z scores
in children with CD during anti-TNF therapy without the changes in weight and BMI Z
scores. Also, we detected elevating SMM Z scores in patients with risk of sarcopenia.
These confirm the association of anti-TNF therapy and beneficial change of nutritional
status. Furthermore our results highlight the known fact, that weight and BMI are not
enough sensitive markers for assessment of nutritional status. The changes of PA in
patients with CD could be considered as a part of optimal recovery. In addition, baseline
HRQoL and disease activity indices may reflect the earlier initiation of anti-TNF therapy,
which seems to be good practice for maintaining physical, social, and emotional wellbeing. All in all, as malnutrition and physical inactivity affect children with IBD during
an important physical and mental developmental period, encouraging them to engage in
more PA, and monitoring their nutritional status should be an essential goal in patient
care.
We also verified that joint involvement is higher in children with CD, than previously
recognized by gastroenterologists. As it affectsthe HRQoL of patients with IBD, referring
patients to a pediatric rheumatologist might be beneficial, by increasing symptom control,
quality of care, and therapeutic management in these patients
