CARDIOVASCULAR DIAGNOSTICS: DIGITAL VARIANCE ANGIOGRAPHY IN CHILDREN AND BLOOD PRESSURE VARIABILITY IN YOUNG ADULTS DIAGNOSED WITH CHILDHOOD DEPRESSION
Nyárády Balázs Bence
Cardiovascular Medicine and Research Division
Dr. Merkely Béla
SE Városmajori Klinikák Tanterme
2025-12-15 13:00:00
Klinikai és kísérlettes angiológiai kutatások
Dr. Dósa Edit
Dr. Farkas Ádám Zoltán
Dr. Nagy Csaba Balázs
Dr. Székely Andrea
Dr. Szappanos Ágnes
Dr. Vallus Gábor
This thesis examines two complementary aspects of CV diagnostics in youth and young adults: the performance of DVA in pediatric endovascular imaging and the role of short‑term BPV as a potential early biomarker of CV risk in individuals with a history of childhood‑onset depression.
Study I. We assessed the diagnostic utility of DVA versus conventional DSA in 132 angiographic image pairs from pediatric patients with extracranial AVMs. DVA yielded consistently higher CNRs, with a median CNRDVA/CNRDSA ratio of 2.00, most notably in upper limb AVMs (2.23). Subjective image quality showed no significant advantage for DVA over DSA; while DSA was slightly preferred in certain vascular territories, the differences were minor and clinically negligible. These findings support the potential of DVA to maintain diagnostic quality while enabling reductions in radiation and contrast dose.
Study II. We examined the relationship between depression burden and short‑term BPV in a sample of 218 young adult probands with childhood‑onset major depression, 206 high‑risk siblings, and 166 low‑risk controls. The number of lifetime depressive episodes significantly predicted increased diastolic BPV, suggesting that recurrent depression may exert an early cumulative physiologic burden on vascular function and highlighting the importance of early CV monitoring.
Together, these studies underscore the significance of both technological innovation and psychosocial context in CV diagnostics. DVA offers a promising avenue for dose reduction in children, whereas short‑term BPV may serve as a sensitive, accessible marker of long‑term CV risk in psychologically vulnerable populations. Both approaches emphasize the need for individualized CV assessment strategies across the lifespan.
