Additive Manufacturing Applications in Pharmaceutical Sciences: osmotic delivery modular tablet and dry media grinding
Borbás Bence
Gyógyszertudományok és Egészségügyi Technológiák Tagozat
Dr. Zelkó Romána
SE Bőr-, Nemikórtani és Bőronkológiai Klinika előadóterme
2026-02-13 13:00:00
Modern Trends in Pharmaceutical Scientific Research
Dr. Antal István
Dr. Antal István
Dr. Barabás J. Imre
Dr. Ujhelyi Zoltán
Dr. Szőke Éva
Dr. Szőcs Levente Péter
Dr. Al-Khrasani Mahmoud
In the first phase of my doctoral research, the application opportunities of the AM in the field of the formulation of modular drug delivery systems were investigated. The SLA technique over the other 3D printing methods due to the high resolution of the tool was chosen. The Raydent Crown & Bridge resin was chosen during the AM of the printlets because of the higher biocompatibility of the material compared to other SLA resins. During the experiments, the elements of the complex osmotic release drug delivery system were optimized, and the delivery systems from the 3D printed frame and the conventionally manufactured elements were successfully assembled. The measurements justified that the tablets, which contained different elements, had different dissolution profiles; thus, the drug delivery can be modified and tailored to the patients’ needs. With the insertion of the push, pull and semipermeable membrane into the 3D printed frame, after an initial burst phase in the dissolution profile, a zero-order release was established from the second hour of the in vitro dissolution studies. Due to this release, the blood level of the API in the patient is going to be more consistent, and because of the prolonged release of the innovative drug delivery system, the dosing regimen suits the patients’ preferences better than an IR tablet.
The second phase of the research aimed at the exploration of the potential applicability of the resin-based printing in one of the basic processes of the pharmaceutical technology, the dry media ball milling. The analysis of the scientific literature demonstrated that one of the main limitations of dry milling is the warmup of the system caused by the collisions of the conventional metal-based grinding media and the grinding jar. Milling balls with the SLA technique were successfully printed, and these printed grinding bodies were suitable for the comminution method. The warmup tests, where additively manufactured milling balls were utilized, showed moderate warmup compared to the conventionally used stainless steel comparator medium.
Based on all the results, the AM can be a promising tool in revolutionizing the pharmaceutical base operations in the industrial environments, and the patient centric therapeutic approaches as well by the implementation of these techniques into the everyday practices of the hospital pharmacies.
