FORMULATION AND RHEOLOGICAL CHARACTERIZATION OF EMULSION TYPE GELS AS DRUG DELIVERY SYSTEMS
Vilimi Zsófia
Gyógyszertudományok és Egészségügyi Technológiák Tagozat
Dr. Zelkó Romána
SE Gyógyszerészeti Intézet Könyvtára
2026-03-06 11:00:00
Modern Trends in Pharmaceutical Scientific Research
Dr. Antal István
Dr. Antal István
Dr. Sebe István
Dr. Berkó Szilvia
Dr. Bagdy György
Dr. Zádori Zoltán
Dr. Siposné Dr. Fehér Pálma Eszter
During the first year of my doctoral studies, I developed a comprehensive overview of the scientific and pharmaceutical significance of gels, with a particular focus on the types of gels available on the Hungarian market. In mapping and systematizing the gels available on the domestic market, I analysed in detail not only the physical and chemical properties of the different types (hydrogels, oleogels, emulgels, bigels), but also their pharmaceutical applications. I published the results of this work in a Hungarian-language paper, contributing to the expansion of the domestic literature.
After classifying the gels, I focused my research on the development of non-hydrogel-type alternative gel systems. I placed particular emphasis on the production of emulgels and oleogels and the investigation of their rheological stability, and drug release properties. During the development of poloxamer-based emulgels, I succeeded in creating formulations that were capable of effectively dissolving lipophilic active ingredients (e.g., clotrimazole) and releasing them in a controlled, programmable manner. I optimized the gel network structure and drug release kinetics by fine-tuning the ratio of poloxamers and HPMC, while improving the local residence time of the formulations by increasing mucoadhesion.
In vitro release studies of the developed systems confirmed that the emulsified gels are capable of continuous drug release for 24 hours, which is of paramount importance for personalized, patient-centered therapies. The use of microfluidic rheological measurement methods has made it possible to quickly test the viscosity of the formulations in a wide shear range from small sample quantities, which is particularly advantageous in modern drug development and quality control.
In summary, my work has succeeded in mapping and systematizing domestic gel types, as well as contributing to the expansion of the toolkit for personalized drug formulation through the development and rheological testing of new, alternative gel systems. The results lay the foundation for the future development of innovative, patient-centered therapeutic solutions that can significantly improve therapeutic efficacy and patient comfort.
