A szérum fetuin-A szerepének vizsgálata anyagcsere és immunmediált betegségekben
Márkus Bernadett
Molecular Medicine
Dr. Enyedi Péter
Budai Irgalmasrendi Kórház előadóterme
2023-06-05 17:00:00
Immunology
Dr. Poór Gyula
Dr. Kalabay László
Dr. Vásárhelyi Barna
Dr. Ágoston Gergely
Dr. Nagy György
Dr. Nagy Géza
Dr. Várnai Réka
The role and significance of fetuin-A, which was discovered in 1944, is still not fully understood. It reduces inflammation at several points: it inhibits macrophage activation and lymphocyte blast transformation and the release of late proinflammatory cytokines. By inhibiting the insulin receptor, it contributes to the development of insulin resistance. It binds to both free fatty acids and Toll-like receptor 4 (TLR4), thereby forming a link between obesity and the associated inflammatory processes. In obese individuals elevated serum fetuin-A levels are associated with type 2 diabetes. Low serum fetuin-A level is associated with higher cardiovascular risk and worse prognosis after ST-elevation myocardial infarction (STEMI).
In our studies we analyzed the serum fetuin-A concentration among patients who survived a myocardial infarct in relation to three polymorphisms of the peroxisome proliferator activated receptors (PPARα intron 7 G/C, PPARγ2 Pro12Ala, PPARγ C161T) (Study 1). In view of its possible immunmodulant role, we determined its level in hereditary angioedema with C1-inhibitor (C1-INH) deficiency in the symptome-free period and during attacks (Study 2), and among SLE patients in connection with the H. pylori infection status (Study 3).
According to our results, the C allele of the PPARα intron 7 G2467C polymorphism is associated with a significantly higher serum fetuin-A level than the non-C allele. The fetuin-A level is strongly determined by the post-infarction state and to a pronounced extent by the PPARα intron 7 G/C polymorphism. The Pro allele of the PPARγ2 Pro12Ala polymorphism is also associated with higher fetuin-A levels but this relationship is not independent of BMI and post-infarction status. There is no significant relationship between the PPARγ C161T polymorphism and fetuin-A concentration. In C1-INH-HAE, plasma fetuin-A levels were elevated during angioedema attacks. In case of SLE patients, H. pylori positive patients had higher serum fetuin-A concentration than negative ones but this difference was not due to post-infection status. In our patient cohort, the activity parameters of SLE did not significantly influence the fetuin-A level.
