Atypical Clinical Presentations of Coagulase-Negative Staphylococcus Infections
Jennifer Adeghate Oluyemisi
Theoretical and Translational Medicine Division
Dr. Kellermayer Miklós
NET Tanácsterem
2024-04-24 10:00:00
Clinical application of basic science results
Dr. Vásárhelyi Barna
Dr. Kristóf Katalin
Dr. Szabó Dorottya
Dr. Visy Beáta
Dr. Szabó András
Dr. Vincze István
Dr. Szalay Balázs
Background: Coagulase-negative staphylococci (CoNS) belong to the normal microbiome; however, they may cause opportunistic infections in neonates and adults with compromised immune systems.
Aims and objectives: We aimed to investigate the unusual presentations of CoNS in various organ systems.
Methods: CoNS strains isolated from urine, blood cultures, and perianal and pharyngeal samples were investigated using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and pulsed-field gel electrophoresis. Additional molecular identification and analysis of CoNS strains was performed on vitreous and aqueous samples of patients with CoNS-related endophthalmitis.
Results and Discussion: S. saprophyticus affected atypical patient populations such as young males. The molecular mass and genetic profile of CoNS isolates from blood cultures and the GI tract of bacteremic neonates showed marked similarity. Severe endophthalmitis benefitted from early vitrectomy over intravitreal injections. Antibiotic resistance is not an issue in treatment of CoNS-related infections.
Conclusion: Despite being part of the commensal microbiome of the skin, CoNS may become virulent pathogens causing significant disease in multiple organ systems in patients of all ages.
