Clinical and Epidemiological Dynamics of COVID-19 Prevention and Treatment with special focus on Chronic Obstructive Pulmonary Disease Patients
Polivka Lőrinc
KÁROLY RÁCZ CONSERVATIVE MEDICINE PROGRAM
Dr. Fekete Andrea
SE Pulmonológiai Klinika tanterme
2025-10-06 13:00:00
Pulmonology
Dr. Losonczy György
Dr. Müller Veronika
Dr. Paróczai Dóra
Dr. Pesti Adrián
Dr. Győrffy Balázs
Dr. Terebessy András
Dr. Böcskei Renáta
The work summarizes investigations of the COVID-19 prevention and treatment dynamics through a clinical epidemiological lens, focusing on key aspects such as treatment of hospitalized patients, prevention and booster vaccinations effect on hospital admissions. The studies conducted within the framework were carried out in Hungary, with a particular emphasis on patients connected to the field of pulmonology. The results of three published datasets are summarized for a more global view representing data from Hungary and from the Department of Pulmonology at Semmelweis University.
The first paper presents a retrospective observational cohort study that evaluates the long-term outcomes of RDV treatment in hospitalized COVID-19 patients at the clinic. By analyzing real-world data, the study assesses the effect of treatment on all-cause mortality, particularly among patients with more severe clinical conditions. This study provides insights into the effectiveness of RDV and its potential benefits for specific patient groups.
The second paper focuses on the impact of booster vaccinations with a specific emphasis on the vulnerable elderly population. The study investigates the effectiveness of booster vaccinations in reducing the risk of hospital admission and mortality. These findings show the importance of vaccination strategies needed for high-risk individuals.
The third paper explores another group with increased susceptibility to respiratory infections: COPD patients. This study investigates vaccine effectiveness and the associated risk of infection and hospitalization.
The clinical epidemiological approaches used in these studies may offer valuable insights into the beneficial use of clinical registries and databases. Furthermore, as these studies were conducted in Hungary, they provide context-specific findings that can contribute to the development of targeted strategies for managing COVID-19 in the local healthcare setting. Overall, this dissertation seeks to contribute to the growing body of knowledge on COVID-19 prevention and treatment by highlighting the importance of clinical epidemiology and providing evidence-based insights as its main conclusions.
Overall, our research was used as direct feedback from clinical practice, and the above discussed results highlight the importance of timely antiviral therapy and booster vaccinations to improve COVID-19 outcomes, particularly in high-risk groups.
