Integrating Nanotechnology and Light: Gold Nanoclusters and Photoswitchable Systems with Biomedical Application
Erdei Eszter
Gyógyszertudományok és Egészségügyi Technológiák Tagozat
Dr. Zelkó Romána
SE Belgyógyászati és Onkológiai Klinika tanterme
2025-12-09 15:15:00
Modern Trends in Pharmaceutical Scientific Research
Dr. Antal István
Dr. Mándity István
Dr. Bősze Szilvia Erika
Dr. Wacha András
Dr. Tábi Tamás
Dr. Lengyel Miléna Bea
Dr. Bóta Attila
AuNCs represent a significant advance in nanotechnology with wide-ranging
applications in biomedical fields, showcasing exceptional properties that can be tailored
for specific uses. Ongoing research into their synthesis, characterization, and
functionalization is crucial for translating these findings into practical applications.
Addressing current challenges and exploring new frontiers will drive the future of AuNCs
in medicine and beyond.
We have created BioGoldNCDB, a comprehensive and freely accessible database of
AuNCs. Each entry in the database was meticulously annotated and manually curated.
This database provides essential information, including CAS numbers and PubMed IDs,
as well as detailed data on biomedical uses, research cell lines, particle dimensions, and
excitation/emission wavelengths.
BioGoldNCDB encompasses 247 publications from 104 journals and features an
intuitive web interface accessible via smartphones, tablets, and computers. Users can finetune
their searches using various filters, and a dedicated help page is available for
guidance. Designed to offer quick insights for beginners, BioGoldNCDB is also a
valuable tool for researchers across multiple disciplines.
The rapidly evolving research landscape surrounding photoswitchable peptides and
foldamers suggests extensive future potential for innovative applications in biomedicine.
Their distinct responsiveness to light stimuli presents an opportunity to develop advanced
therapeutic agents, enhancer systems for drug delivery, and novel biosensing platforms.
As methodologies in synthetic biology and advanced materials science continue to
improve, it is anticipated that these photoswitchable systems will further integrate into
precision medicine, providing targeted and effective solutions to complex medical
challenges. Pyridazinone and triazole derivatives were modified using PC, enabling Nalkylation
without genotoxic reagents.
With ongoing advancements in the chemistry and methodology related to these
systems, the prospect of establishing mechanistic pathways for dynamic regulation in
therapeutic scenarios becomes increasingly feasible. Continuous innovation in
understanding the interactions between photoresponsive materials and biological systems
will serve as a cornerstone for developing next-generation medical treatments.
