INNOVATIVE IN VITRO DISSOLUTION STUDIES FROM VARIOUS PHARMACEUTICAL DOSAGE FORMS AND VIS IMAGING USING ARTIFICIAL NEURAL NETWORKS
Kakuk Melinda
Gyógyszertudományok és Egészségügyi Technológiák Tagozat
Dr. Zelkó Romána
Semmelweis Egyetem, Egyetemi Gyógyszertár Gyógyszerügyi Szervezési Intézet, Zalai terem
2025-12-05 11:30:00
Modern Trends in Pharmaceutical Scientific Research
Dr. Antal István
Dr. Kállai-Szabó Nikolett
Dr. Gieszinger Péter
Dr. Mirzahosseini Arash
Dr. Szőke Éva
Dr. Angi Erzsébet Réka
Dr. Dunkel Petra
Dr. Madarász-Kádár Szabina
During my research, one of my main objectives was to explore the application of a rapid and non-destructive method capable of predicting the buoyancy properties of tablets. To achieve this, I first examined the effect of various dissolution media on drug release. Subsequently, I investigated gastroretentive floating drug delivery systems using in vitro dissolution studies to monitor their floating behavior and its progression over time. For this purpose, I prepared directly compressed caffeine-containing tablets with identical composition but using different compression forces. Based on the hardness of these tablets, I inferred their floating characteristics and drug release rates.
I calculated the density of the tablets using their physical parameters - shape, height, and weight - to support their influence on buoyancy. Microscopic images of the tablet surfaces were also taken, and I correlated surface gloss with tablet hardness. My research demonstrated that, in addition to determining physical parameters, microscopic imaging can be used to predict the buoyancy of floating tablets. Consequently, the dissolution profile may also be predicted. The procedure is fast, non-destructive, and may be suitable for quality control of floating tablets, through which tablets with altered floating properties resulting from manufacturing deviations can likely be detected. Furthermore, image processing algorithms and artificial neural networks were employed to classify the tablets based on their hardness and buoyancy.
The next phase of my work focused on evaluating the applicability of ICP-OES in combination with in vitro drug release testing. In this experiment, I prepared immediate-release ibuprofen sodium pellet cores as a model compound and simultaneously determined drug release and sodium concentration in-line. The results confirmed that both methods yielded comparable outcomes. Additionally, I successfully simulated an innovative drug delivery approach using pellets loaded into a straw. To mimic continuous flow and dynamic pH changes, a peristaltic pump was used, creating more biorelevant conditions.
