A szerotonin transzporter- és az interleukin-6 gén interakciója a distalis és proximalis stresszorokkal a befejezett öngyilkosság, a korábbi öngyilkossági kísérletek és a szuicid ideáció hátterében
Bokor János
János Szentágothai Neurosciences
Dr. Bereczki Dániel
Semmelweis Egyetem Patológiai, Igazságügyi és Biztosítási Orvostani Intézet, Üllői út 93. Bognár Gyula terem
2026-02-27 14:00:00
Biolgogical psychiatry
Dr. Faludi Gábor
Dr. Gonda Xénia
Dr. Makkos Zoltán
Dr. Dósa Ágnes
Dr. Kovács József
Dr. Kristóf István András
Dr. Rácz Gergely
In my research, I aimed to identify key molecular risk factors for suicide, with a particular focus on the independent effects of the 5-HTTLPR and IL6 genes on various suicidal phenotypes - namely, completed suicide, prior suicide attempts, current suicidal ideation, and other contemporary suicidal markers. I also examined the gene × environment interaction effects of these genes in the context of different types of stressors. My findings revealed a complex pattern of associations among genes, stressors, and suicidal phenotypes, underscoring that the genetic underpinnings of suicide risk can only be elucidated by considering multiple interacting factors. A more precise understanding of the molecular basis of suicidal behavior and the role of specific genetic influences is essential for the early identification of individuals at risk, and for enhancing future efforts to reduce suicide mortality.
