A fertőzések és a mikrobiom szerepe a glioblasztóma viselkedésében és prognózisában: klinikai és molekuláris összefüggések vizsgálata
Berényi György
János Szentágothai Neurosciences
Dr. Bereczki Dániel
Semmelweis Egyetem, Idegsebészet és Neurointervenciós Klinika, Budapest, Laky Adolf u. 44-46., Könyvtár
2026-02-23 13:00:00
Clinical Neurological Research
Dr. Kovács Tibor
Dr. Sipos László
Dr. Lakatos Botond
Dr. Vastagh Ildikó
Dr. Törő Klára Andrea
Dr. Dénes Judit
Dr. Nyáry István
Brain tumors, particularly high-grade gliomas (HGGs), are among the most common primary central nervous system tumors with the worst prognosis. In addition to genetic mutations, the role of the microbiome and mycobiome is increasingly coming to the forefront in their development and progression, as they can influence tumor growth, the tumor microenvironment, and response to therapy.
In our retrospective study, we analyzed data from 2008 patients operated on for HGG. Postoperative surgical site infections developed in 26 cases among HGG patients. We compared these cases to a control group matched for age, diagnosis, and therapy, and analyzed survival outcomes. The median survival of HGG patients who developed postoperative surgical site infections was slightly lower; however, their mean survival was significantly longer compared to the control group. The survival data showed high variability, suggesting that the effect of infection is heterogeneous: infections occurring at the time of HGG diagnosis were associated with shorter survival, while later-onset postoperative surgical site infections were linked to longer, outstanding survival. The IDH mutation status of HGG patients influenced survival, but no association was found between surgical site infection and IDH status.
In a low-case-number exploratory study, we analyzed bacterial and fungal communities from tumor tissue, tumor-adjacent tissue (TAT), blood, and stool samples of five brain tumor patients using 16S rRNA and ITS sequencing. The results showed that the gut microbiome and mycobiome exhibited unique patterns in every patient. The microbiome composition of the tumor, TAT, and blood was relatively uniform. In contrast, the mycobiome profile was much more heterogeneous. Fungal communities in the tumor followed a specific pattern, independent of microbiome patterns, potentially holding independent biological and therapeutic significance.
Both of our studies confirm that microbial factors—bacteria, fungi, or opportunistic infections—may play a dual role in the pathogenesis of brain tumors and the clinical outcome of the disease. The specific patterns of the microbiome and mycobiome, as well as the heterogeneous effects of infections on survival, indicate that the relationship between tumors and microbes is extremely complex.
