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Analysis of the genetic background of thyroid cancer and the outcomes of preoperative assessment

hungarian

Kiss András

KÁROLY RÁCZ CONSERVATIVE MEDICINE PROGRAM

Dr. Fekete Andrea

SE Belgyógyászati és Onkológiai Klinika, Simonyi terem

2026-11-02 14:00:00

Anyagcsere betegségek

Dr. Lakatos Péter

Dr. Lakatos Péter András és Dr. Kósa János Pál

Dr. Huszty Gergely Dénes

Dr. Dénes Judit

Dr. Tamás László

Dr. Kovács Gábor László

Dr. Dános Kornél

1. In summary, we concluded, that thyroid cancer can be seen more frequently after numerous primary malignancies, and the risk of second primary malignancies after thyroid cancer is increased, than would be expected in the general population. We established, that the sporadic co-occurrence of thyroid and breast cancer is at least partly caused by an increased germline oncogene SNP burden. To our best knowledge, this association as a genetic predisposition has not been described previously in the literature. 2. Aiming to improve the diagnostic accuracy in distinguishing benign from malignant thyroid nodules with indeterminate cytology, we found a 30 kind of miRNA expressed differently in papillary thyroid cancer compared to intact thyroid tissue. This was the most comprehensive miRNA study in relation to PTC so far. Some of the identified associations have not been described before in the literature. Thus, this study provided the largest number of original molecular data derived from papillary thyroid cancer samples with matched controls and the most comprehensive set of analyzed miRNAs. We also demonstrated different miRNA profiles associated with different clinicopathological variables, providing a better insight of papillary thyroid cancer biologic behavior. These findings point toward novel diagnostic and moreover, therapeutic strategies for PTC patients. 3. We also established that lobectomy in preoperatively diagnosed low-risk thyroid cancer, according to either ATA or ETA guidelines, results in frequent completion thyroidectomy. This could be partly be explained by our finding that the preoperative assessment of such patients is far from reliable. The size of the malignant thyroid nodule associated weakly with the postoperative risk factors, only the presence of angioinvasion could be predicted based on the tumor size. As a consequence, a better, possibly genetic or epigenetic based preoperative set of criteria would be necessary, to decide more appropriately the initial surgical approach. Until that, we advocate for more one-step total thyroidectomy, avoiding the possible need for a second surgery.