Gyógyszertudományok és Egészségügyi Technológiák Tagozat
Dr. Zelkó Romána
SE Gyógyszerészeti Intézet Könyvtára
2026-10-09 11:30:00
Modern Trends in Pharmaceutical Scientific Research
Dr. Antal István
Dr. Antal István
Dr. Barabás J. Imre
Dr. Ujhelyi Zoltán
Dr. Szőke Éva
Dr. Al-Khrasani Mahmoud
Dr. Szőcs Levente Szilárd
The objective of my doctoral work was to investigate core–shell structured systems. I examined the applicability of microfluidics for the characterization of inert carriers. In addition, my research addressed whether inert minitablet cores produced by stereolithography (SLA) 3D printing could be integrated into conventional fluid-bed layering and coating processes to develop a modified-release multiparticulate drug delivery system.
Inert minitablet cores with a diameter of 3.0 mm and a height of 2.5 mm were fabricated from FLEX80 photopolymer resin using an Original Prusa SL1S SPEED printer via masked stereolithography. The cores were layered with ibuprofen sodium by bottom-spray fluidised-bed processing up to a dry matter-to-core mass ratio of 1:1, after which film coatings with weight gains of 10, 20, and 30% w/w were applied from an aqueous Eudragit® RS dispersion.
The printed cores had a mean mass of 18.56 mg, a mean crushing strength of 483.4 ± 1.4 N, and a friability of 0%. Image analysis (n = 75) indicated isotropic dimensional growth throughout the processing steps. Raman microspectroscopic mapping confirmed the intended layered structure. In the in vitro dissolution studies, the ibuprofen sodium-layered minitablets without a modified-release film coating released more than 85% of the drug within 10 minutes. For particles with a functional film coating, drug release was primarily governed by the thickness of the polymer coating. At a 10% film coating, 70% drug release occurred within 8 hours, whereas at 20% and 30% film coatings, 70% drug release was achieved within 16 and 24 hours, respectively.
My results confirmed that SLA 3D printing and conventional pellet-technology operations can be successfully integrated within a proof-of-concept system. Furthermore, the behaviour of drug-carrier inert cores was investigated under a microscope in a small-volume fluid flow under different pH conditions. The presented approach may indirectly support patient-centric dosage form design; in the present work, personalisation was conceptualised as the potential for geometric modification of digitally designed cores, rather than as the experimental optimisation of a patient-specific dose or release profile.
